Robert T Dirksen Selected Research

Central Core Myopathy (Central Core Disease)

6/2021	Altered Ca2+ Handling and Oxidative Stress Underlie Mitochondrial Damage and Skeletal Muscle Dysfunction in Aging and Disease.
1/2017	Reduced threshold for store overload-induced Ca2+ release is a common defect of RyR1 mutations associated with malignant hyperthermia and central core disease.
1/2015	Oxidative stress, mitochondrial damage, and cores in muscle from calsequestrin-1 knockout mice.
2/2013	Novel excitation-contraction uncoupled RYR1 mutations in patients with central core disease.
1/2013	Ca2+ release in muscle fibers expressing R4892W and G4896V type 1 ryanodine receptor disease mutants.
11/2011	Defects in Ca2+ release associated with local expression of pathological ryanodine receptors in mouse muscle fibres.
1/2011	Muscle weakness in Ryr1I4895T/WT knock-in mice as a result of reduced ryanodine receptor Ca2+ ion permeation and release from the sarcoplasmic reticulum.
12/2010	The I4895T mutation in the type 1 ryanodine receptor induces fiber-type specific alterations in skeletal muscle that mimic premature aging.
12/2009	Characterization and temporal development of cores in a mouse model of malignant hyperthermia.
11/2007	An Ryr1I4895T mutation abolishes Ca2+ release channel function and delays development in homozygous offspring of a mutant mouse line.

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Robert T Dirksen Research Topics

Disease

23	Malignant Hyperthermia 01/2022 - 10/2004
16	Central Core Myopathy (Central Core Disease) 06/2021 - 07/2002
9	Muscular Diseases (Myopathy) 06/2021 - 07/2002
9	Myotonic Dystrophy (Dystrophia Myotonica) 10/2016 - 08/2005
6	Contracture 01/2022 - 02/2006
5	Rhabdomyolysis 06/2021 - 06/2009
4	Sudden Death 09/2015 - 06/2009
4	Muscle Weakness 09/2013 - 07/2002
3	Muscular Dystrophies (Muscular Dystrophy) 06/2021 - 11/2008
3	Paralysis (Palsy) 11/2020 - 03/2010
3	Fatigue 10/2017 - 01/2013
3	Heart Failure 01/2014 - 07/2003
3	Myotonia 12/2010 - 01/2007
2	Neoplasms (Cancer) 12/2022 - 11/2008
2	Neurodegenerative Diseases (Neurodegenerative Disease) 03/2022 - 11/2008
2	Heat Stress Disorders (Heat Cramp) 01/2022 - 11/2014
2	Congenital Structural Myopathies (Centronuclear Myopathy) 11/2018 - 09/2013
2	Long QT Syndrome 01/2018 - 10/2016
2	Polymorphic catecholergic ventricular tachycardia 01/2017 - 08/2006
2	Inborn Genetic Diseases (Disease, Hereditary) 10/2016 - 03/2012
2	Body Weight (Weight, Body) 09/2015 - 01/2013
2	Minicore Myopathy with External Ophthalmoplegia 03/2010 - 10/2004
2	Hypoxia (Hypoxemia) 11/2008 - 07/2008
2	Channelopathies 12/2007 - 04/2007
2	Cardiomyopathies (Cardiomyopathy) 08/2006 - 07/2003
1	Alzheimer Disease (Alzheimer's Disease) 03/2022
1	Mitochondrial Diseases (Mitochondrial Disease) 03/2022
1	Atrophic Muscular Disorders 06/2021
1	Sarcopenia 06/2021
1	King Denborough syndrome 11/2020
1	Distal Myopathies (Distal Muscular Dystrophy) 11/2020
1	Myalgia 11/2020
1	Multiple pterygium syndrome 11/2020
1	Spinal Muscular Atrophy (Progressive Muscular Atrophy) 01/2020
1	Muscular Atrophy (Muscle Atrophy) 01/2019
1	Crush Injuries 01/2019
1	Hypertrophy 10/2018
1	Ventricular Remodeling 10/2018
1	Cardiovascular Diseases (Cardiovascular Disease) 01/2018
1	Native American myopathy 10/2017
1	Huntington Disease (Huntington's Disease) 01/2017
1	Seizures (Absence Seizure) 10/2016
1	Pain (Aches) 01/2016
1	Atrophy 09/2015
1	Necrosis 07/2014
1	Fibrosis (Cirrhosis) 07/2014

Drug/Important Bio-Agent (IBA)

35	Ryanodine Receptor Calcium Release Channel (Ryanodine Receptor)IBA 04/2021 - 07/2002
9	Proteins (Proteins, Gene)FDA Link 01/2020 - 10/2004
6	CalciumIBA 11/2020 - 02/2006
5	Anesthetics (Anesthetic Agents)IBA 01/2022 - 02/2006
4	Halothane (Fluothane)FDA Link 01/2022 - 02/2006
4	Caffeine (No Doz)FDA LinkGeneric 01/2022 - 02/2006
3	RNA (Ribonucleic Acid)IBA 01/2017 - 12/2005
3	Messenger RNA (mRNA)IBA 01/2007 - 08/2005
2	IonsIBA 10/2017 - 12/2007
2	Myotonin-Protein KinaseIBA 10/2016 - 01/2007
2	Carrier Proteins (Binding Protein)IBA 09/2015 - 07/2009
2	Superoxides (Superoxide)IBA 11/2008 - 07/2008
2	ChloridesIBA 12/2007 - 04/2007
2	Chloride Channels (Chloride Channel)IBA 12/2007 - 01/2007
2	Protein Isoforms (Isoforms)IBA 01/2007 - 07/2002
1	Reactive Oxygen Species (Oxygen Radicals)IBA 03/2022
1	IronIBA 03/2022
1	Oxygen (Dioxygen)IBA 06/2021
1	NitrogenIBA 06/2021
1	Adenosine Monophosphate (AMP)IBA 01/2021
1	Pharmaceutical PreparationsIBA 01/2020
1	4-Aminopyridine (4 Aminopyridine)FDA Link 01/2019
1	Potassium Channel Blockers (Blockers, Potassium Channel)IBA 01/2019
1	Tamoxifen FDA LinkGeneric 11/2018
1	Transcription Factors (Transcription Factor)IBA 10/2018
1	myocardinIBA 10/2018
1	gamma-Aminobutyric Acid (GABA)IBA 01/2018
1	Cysteine (L-Cysteine)FDA Link 10/2017
1	Biomarkers (Surrogate Marker)IBA 10/2016
1	Cyclic NucleotidesIBA 10/2016
1	Purinergic Receptors (Receptors, Purine)IBA 01/2016
1	Adenosine Triphosphate (ATP)IBA 01/2016
1	Calcium-Calmodulin-Dependent Protein Kinase Type 2IBA 09/2015
1	Calcium-Calmodulin-Dependent Protein KinasesIBA 09/2015
1	AntioxidantsIBA 09/2015
1	Acetylcysteine (Siran)FDA LinkGeneric 09/2015
1	AcidsIBA 09/2015
1	Drinking WaterIBA 09/2015
1	6- hydroxy- 2,5,7,8- tetramethylchroman- 2- carboxylic acid (Trolox)IBA 09/2015
1	Creatine Kinase (Creatine Phosphokinase)IBA 07/2014
1	Sarcoglycans (beta Sarcoglycan)IBA 07/2014
1	DystrophinIBA 07/2014
1	Cytoskeletal ProteinsIBA 01/2014
1	Phosphoric Monoester Hydrolases (Phosphatases)IBA 09/2013
1	CalsequestrinIBA 01/2013
1	MicroRNAs (MicroRNA)IBA 03/2012
1	Calcium Channels (Calcium Channel)IBA 03/2012
1	AICA ribonucleotide (ZMP)IBA 01/2012

Therapy/Procedure

4	Therapeutics 01/2020 - 10/2016
2	Anesthesia 11/2014 - 02/2006
1	Radiotherapy 12/2022
1	Intraperitoneal Injections 09/2015
1	Ligation 01/2015
1	Denervation 09/2013